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KMID : 0361520050160040279
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Korean Journal of Psychopharmacology
2005 Volume.16 No. 4 p.279 ~ p.284
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Add-On Therapy of Quetiapine for Bipolar Disorder ： A 6 Month, Prospective Trial
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배치운
김태석/이영지/김정진/이수정/이창욱/이철/백인호
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Abstract
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Objectives：This study was conducted to evaluate the overall effectiveness and tolerability of adjunctive quetiapine in the long-term treatment of bipolar disorder as a continuation therapy. Methods：Twenty-three bipolar I patients participated and required to have quetiapine add-on treatment in combination with existing or new mood stabilizers. Clinical assessment was carried out using Young Mania Rating Scale (YMRS), Clinical Global Impression (CGI), Hamilton Depression Rating Scale-17 item, Simpson-Angus Rating Scale and Barnes Akathisia Rating Scale at baseline, 1, 4, 12 and 24 weeks. Results：The YMRS and CGI decreased significantly from baseline to endpoint by 89.7% and 78.3%, respectively (p≶0.0001；p≶0.0001). Twenty-two patients exhibited at least 50% improvement on YMRS score by the end of the study. Conclusion：This study suggests that quetiapine may hold a promise as an adjunct in the long-term treatment of bipolar disorder.
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KEYWORD
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